The Science Behind LSD

The Science Behind Microdosing LSD – What Research Tells Us


LSD, or lysergic acid diethylamide, is a powerful psychedelic substance that has captivated the attention of researchers and the public for decades. While its full-dose effects are well-documented, a new trend has emerged: microdosing. Microdosing involves taking sub-perceptual doses of a psychedelic substance, often one-tenth of a recreational dose, in an attempt to enhance creativity, boost mood, and improve cognitive function. This article delves into the science behind microdosing LSD, investigating its potential benefits, risks, and the state of current research.

What is Microdosing?

Before diving into the effects and the science of LSD microdosing, it is crucial to define the practice properly. Microdosing refers to the consumption of very low, sub-perceptual doses of psychedelic substances like LSD, usually about one-tenth to one-twentieth of a recreational dose. Users typically follow a regimen where doses are taken every three to four days.
The main purpose of this practice is not to experience the full-blown psychedelic effects associated with higher doses, but rather to purportedly enhance everyday functioning – think of it as trying to get the “background” benefits without the overt “foreground” effects.

The Proposed Benefits of Microdosing

The internet is replete with anecdotal reports singing praises of microdosing for its alleged benefits in various areas. Let’s explore some of these proposed benefits.

Cognitive Enhancement

One of the most commonly cited advantages of microdosing LSD is cognitive enhancement. Many microdosers report increased focus, creativity, and problem-solving skills. In theory, these benefits could be explained by the drug’s effects on brain connectivity, allowing for more flexible thought patterns.

Mood Enhancement

Another popular claim is that microdosing can improve mood, reducing symptoms of depression and anxiety. The theory is that LSD, even in small doses, can influence serotonin receptors, similar to traditional antidepressants.

Physical Energy

Some users report increased physical energy and reduced fatigue when microdosing LSD. They suggest that the practice helps them maintain a more active lifestyle, both in their work and personal life.

The Science Behind Microdosing LSD

While anecdotal reports paint a promising picture, what does the scientific literature say? Let’s look at the current state of research.

Neuroscience of Microdosing

Recent studies have shown that LSD, even in microdoses, has a notable effect on brain connectivity. Research published in the “Journal of Psychopharmacology” (2021) showed increased connectivity in regions associated with higher-level cognitive functions during LSD microdosing. This could potentially explain the reported cognitive benefits.

Clinical Research

Clinical research on the effects of microdosing LSD is still in its infancy. A double-blind, placebo-controlled study conducted by the Imperial College London (2022) found no significant difference between the microdosing group and the placebo group in terms of cognitive performance, mood, and quality of life measures. However, researchers noted that the lack of significant results could be due to various factors such as dosage and individual differences, suggesting that more research is needed.

The Risks and Unknowns of Microdosing

While the proposed benefits of microdosing LSD seem attractive, it’s important to remember that there are still many unknowns about this practice. Long-term effects of microdosing are largely unknown due to the lack of longitudinal studies. Furthermore, as LSD is a schedule I controlled substance, microdosing is illegal in many regions, which could lead to legal consequences.


Microdosing LSD is a burgeoning field of interest, both in scientific research and the broader public discourse. While anecdotal reports abound with positive experiences, rigorous scientific investigation is still catching up. As with any drug use, potential benefits must be weighed against possible risks and legality. The future of microdosing LSD will hinge on further research, bringing clearer understanding of its effects and potential therapeutic applications. For now, it remains a fascinating, yet largely mysterious, area of study.


Why You Should Buy Psychedelics With Shroomhub – Online Canadian Magic Shroom Dispensary

Shroomhub is your most trusted online mushroom dispensary in Canada, dutifully providing quality products at the most competitive prices to customers across all territories. Our broad product range includes everything from micro-dose mushroom capsules to Psilocybin containing dried mushrooms, and even extends to LSD products and DMT. Shop online today and take advantage of our low prices and rest easy knowing the Shroomhub team as your order taken care of.

Similar Posts